Posted
Mon., March 18
Organization
The Kadoch Laboratory at the Dana-Farber Cancer Institute, Harvard Medical School, Broad Institute, and Howard Hughes Medical Institute
Position Description
The Kadoch Laboratory at the Dana-Farber Cancer Institute, Harvard Medical School, Broad Institute and Howard Hughes Medical Institute is seeking a highly qualified individual who has recently obtained or is about to obtain a BA/BS degree (or higher) to join their vibrant research team as a Computational Biologist focused on cancer biology, epigenetics, and chromatin regulation.
Their lab uses multidisciplinary approaches including biochemistry, biophysics, structural biology, chemical biology, and functional genomics and epigenomics to explore the mechanisms of chromatin remodeling complexes, which are among the most frequently mutated cellular entities in human cancers and other diseases. Their computationally-centered projects in the lab are therefore highly diverse and involve extensive genomics (i.e. analysis of many NGS methods including DNA sequencing, RNA sequencing (RNA-seg), ATAC-seg, ChlP-seg, CUT&RUN, CUT&TAG, single-cell ATAC+RNA-seq among other approaches), analysis of functional screening datasets (i.e. genome-wide as well as targeted CRISPR- and base editing-based screens for cell fitness or other cellular outcomes), 3D structural biology (i.e. use of Pymol and UCSF Chimera for structural analysis, mapping mutations, etc.), analysis and integration of mass-spectrometry proteomics datasets, and artificial intelligence/machine learning (AI/ML) and systems biology-focused efforts (i.e. large genomics and proteomics dataset analysis and integration, Deepmind, Alphafold, Rosetta, and other approaches).
Their collection of ongoing projects involve collaborations with laboratories across the Harvard/MIT research centers and hospitals in Boston and Cambridge as well as with groups across the country and internationally. This is a unique opportunity with significant potential for the student to work directly with the PI as well as with senior graduate students and postdoctoral fellows to carry forward independent projects resulting in authorship on publications and opportunities to present work at local, national, and international meetings.
Position Requirements
- Coding experience (i.e. in R, Python, or other languages) relevant to bioinformatics/computational biology
- Familiarity working in a Unix environment and use of SLURM or similar job scheduler (high performance computing)
- Working knowledge of genomic technologies and bioinformatic processes and/or structural biology
- Ability to both implement and develop new bioinformatic pipelines in shell scripts
- Interest and proven abilities in data visualization
- Proficiency in documenting research processes to ensure reproducibility (e.g. markdown syntax and Git/GitHub) as well as experience in one or more of the following areas: computational biology/computer science, molecular biology, genetics and/or genomics, cell biology, and protein biochemistry and/or structural biology through focused prior dry or wet lab research experience as well as undergraduate coursework
Time Commitment
Full-time, minimum two-year commitment
Compensation
TBD
Apply
To apply, please contact Cigall Kadoch, PhD directly at [email protected]u for more information if interested (along with CV/resume) and please copy Dr. Kadoch's assistant, Ms. Kristen Applegate at [email protected].
