Posted
Thurs., March 9
Organization
The Kadoch Lab
Position Description
The Kadoch Laboratory at the Dana-Farber Cancer Institute, Harvard Medical School, Broad Institute, and Howard Hughes Medical Institute is seeking a post-graduate student to join their vibrant research team as a computational biologist focused on cancer biology, epigenetics, and chromatin regulation. Most often successful candidates have an interest in applying to top-tier graduate and/or medical school (PhD/MD/MD-PhD) programs after their tenure in the Kadoch Lab or to function as a senior staff computational biologist in the academic setting for years to come. Dr. Kadoch is firmly committed to mentorship, and to date, all postbac computational biology lab members in this position have gone on to pursue PhD, MD, or MD/PhD programs at highest-tier institutions.
Their lab uses multidisciplinary approaches including biochemistry, biophysics, structural biology, chemical biology, and functional genomics to explore the mechanisms of chromatin remodeling complexes, which are among the most frequently mutated cellular entities in human cancers and other diseases. As such, their computationally-centered projects in the lab are highly diverse and involve extensive genomics (i.e., analysis of many NGS methods, analysis of functional screening datasets, 3D structural biology, analysis and integration of mass-spectrometry proteomics datasets, and artificial intelligence/machine learning (AI/ML) and systems biology-focused efforts.
Ongoing projects involve collaborations with laboratories across Harvard/MIT research centers and hospitals in Boston and Cambridge, as well as with groups across the country and internationally.
This is a unique opportunity with significant potential for the student to work directly with the PI as well as with senior graduate students and postdoctoral fellows to carry forward independent projects resulting in authorship on publications and opportunities to present work at local, national, and international meetings.
Position Requirements
- Coding experience (i.e., R, Python, or other languages) relevant to bioinformatics/computational biology, familiarity with working in a Unix environment, and use of SLURM or similar job scheduler (high performance computing)
- Working knowledge of genomic technologies and bioinformatic processes and/or structural biology
- Ability to both implement and develop new bioinformatic pipelines in shell scripts
- Interest and proven abilities in data visualization (such as in ggplot2, matplotlib, D3.js, etc.)
- Experience in one or more of the following areas: computational biology/computer science, molecular biology, genetics and/or genomics, cell biology, and protein biochemistry and/or structural biology through focused prior dry or wet lab research experience (i.e., 1-2 years in research laboratories with strong letters of recommendation) as well as undergraduate coursework
Time Commitment
Full-time, with a two-year commitment
Compensation
TBD
Apply
For more information, and to apply, email your CV/resume to Cigall Kadoch, Ph.D. directly and copy Dr. Kadoch’s assistant, Ms. Kristen Applegate.
