Chemical Physics

CHEM W0001x Preparation for College Chemistry Prerequisites: High school algebra or the instructor's permission. Recommended Preparation: high school physics and chemistry. Not for credit toward the bachelor's degree. Given on a Pass/Fail basis only. This course is preparation for Chemistry W1403 or the equivalent, as well as for other science courses. It is intended for students who have not attended school for sometime or who do not have a firm grasp of high school chemistry. Topics include atomic and nuclear structure, nomenclature, chemical bonding and its relation to molecular structure, chemical reactions, stoichiometry, periodic properties of elements, equilibria, gas laws, acids and bases, and kinetics. Recitation Section Required.

CHEM C1403x-C1404y General Chemistry (Lecture) 3.5 pts. Prerequisites: concurrent registration in MATH V1101; for C1404: CHEM C1403 or W1403. Preparation equivalent to one year of high school chemistry is assumed and concurrent registration in Calculus I. Students lacking such preparation should plan independent study of chemistry over the summer or take CHEM W0001 before taking C1403. Topics include stoichiometry, states of matter, chemical equilibria, acids and bases, chemical thermodynamics, nuclear properties, electronic structures of atoms, periodic properties, chemical bonding, molecular geometry, introduction to organic and biological chemistry, solid state and materials science, polymer science and macromolecular structures, chemical kinetics, coordination chemistry, and electrochemistry. Although C1403 and C1404 are separate courses, students are expected to take both terms sequentially. the order of presentation of topics may differ from the order presented here, and from year to year. Recitation Section Required.

CHEM W1403x or y-W1404y General Chemistry ( Lecture) 3.5 pts. Prerequisites: concurrent registration in MATH V1101; for C1404: CHEM C1403 or W1403. Topics include kinetic theory of gases, solutions, equilibria, oxidation-reduction, reactions, thermodynamics, chemical kinetics, the electronic structure of atoms, chemical bonding and its relationship to the geometries of molecules, periodic properties of the elements, transition metal complexes, and an introduction to organic chemistry and biochemistry. Recitation Section Required.

CHEM W1403y General Chemistry I 3.5 pts. Corequisites: MATH V1101 Topics include stoichiometry, states of matter, chemical equilibria, acids and bases, chemical thermodynamics, nuclear properties, electronic structures of atoms, periodic properties, chemical bonding, molecular geometry, introduction to organic and biological chemistry, solid state and materials science, polymer science and macromolecular structures, chemical kinetics, coordination chemistry, and electrochemistry. Recitation Section Required.

CHEM W1500x or y General Chemistry Laboratory. 3 pts. Corequisites: CHEM C1403 or W1403. Laboratory Fee: $140. An introduction to basic techniques of modern experimental chemistry, including quantitative procedures and chemical analysis. A Lab Lecture section is also required for this course (W1501).

CHEM C1604x Second Semester General Chemistry (Intensive) 3.5 pts. Prerequisites: A grade of "B" or better in CHEM C1403 or W1403 or acceptable performance on the Department placement exam. Corequisites: Calculus II. Topics include: Gases (Kinetic Theory of Gases); Binary Collision Model for Chemical Reactions; Chemical Kinetics; Acid-base Equilibria; Thermochemistry (Thermodynamics I); Thermodynamics II Spontaneous Processes; Chemical Bonding in Polyatomic Molecules. Recitation Section Required.

CHEM C2408y First-Year Seminar 1 pt. Prerequisites: CHEM C1403, C1604, or C3045 or the instructor's permission. A one-hour weekly lecture, discussion, and critical analysis of topics that reflect problems in modern chemistry, with emphasis on current areas of active chemical research.

CHEM W2507x or y Intensive General Chemistry Laboratory 3 pts. Prerequisites: CHEM C1604 or C3045. Laboratory Fee: $140. An introduction to basic techniques and practices of modern experimental chemistry, including qualitative procedures and chemical analysis. This course differs from CHEM W1500 in its emphasis on instrumentation and methods. Students must also attend the compulsory Mentoring Session. Please check the Directory of Classes for details.

CHEM C3045x-C3046y Intensive Organic Chemistry for First-Year Students (Lecture) 3.5 pts. Prerequisites: A grade of 5 on the Chemistry Advanced Placement exam and an acceptable grade on the Department placement exam. Not open to students who have taken other courses in college-level chemistry. Premedical students may take CHEM C3045, C3046, and C3545 to meet the minimum requirements for admission to medical school. This course covers the same material as CHEM C3443-C3444, but is intended for students who have learned the principles of general chemistry in high school. The level of instruction is appropriate for those who have not had a college course in general chemistry. Students enrolled in CHEM C3045-C3046 are expected to enroll concurrently in CHEM W2507. Recitation Section Required.

CHEM C3079x-C3080y Physical Chemistry, I and II 4 pts. Prerequisites: CHEM C1403 and C1404, or C1604, or C3045 and C3046; PHYS V1201-V1202 is acceptable, PHYS C1401-C1402 is recommended, or the equivalent; and MATH V1101-V1102 or V1207-V1208. Recommended corequisite: CHEM C3085-C3086. Elementary but comprehensive treatment of the fundamental laws governing the behavior of individual atoms and molecules and collections of them. C3079: The thermodynamics of chemical systems at equilibrium and the chemical kinetics of nonequilibrium systems. C3080: The quantum mechanics of atoms and molecules, the quantum statistical mechanics of chemical systems, and the connection of statistical mechanics to thermodynamics. Recitation Section Required.

CHEM C3081y Physical Chemistry III - Special Topics in Physical Chemistry 2 pts. Prerequisites: CHEM C3079-3080 (Physical Chemistry I and II) The objective of Physical Chemistry lll is to discuss and analyze topics in forefront areas of physical chemistry research. The research topics will be selected in class discussions at the beginning of the semester. All of the topics extend from equilibrium to nonequilibrium ultrafast dynamic processes. The application of linear and nonlinear spectroscopies to probe systems of interest will be discussed. Examples of possible topics include : 1) Biomolecular processes, e.g. DNA - drug and DNA - protein - interactions. 2) Plasmonic nanoparticle, e.g. Au and Ag, interactions with molecules in ground and excited electronic states, e.g. energy and electron transfer, enhancement of molecular optical processes, e.g. absorption, Raman, nonlinear, circular dichroism and optical spectroscopies. 3) Probing environmental interfaces, e. g. air/water, oil/water, atmospheric aerosoles, and soil/water, using the interface selective second harmonic and vibrational sum frequency spectroscopies 4) Guest lecturers on topics such as molecular electronics , graphene, etc. The individual students will write a report of 2 to 3 pages in length, on a subject of their interest.

CHEM C3085x-C3086y Physical and Analytical Chemistry Laboratory 4 pts. Prerequisites: CHEM C3085 is prerequisite for C3086. Corequisites: CHEM C3079 for CHEM C3085 and C3080 for C3080. Laboratory Fee: $125 per term. Techniques of experimental physical chemistry and instrumental analysis, including infrared and ultraviolet spectrophotometry, magnetic resonance, electroanalytical methods, calorimetry, reaction kinetics, hydrodynamic methods, and applications of digital computers to the analysis of experimental data.

CHEM C3098x or y Supervised Independent Research 4 pts. Prerequisites: The permission of the professor in charge for entrance, and the permission of the departmental representative for aggregate points in excess of 12 or less than 4. Laboratory Fee: $105 per term. This course may be repeated for credit (see major and concentration requirements). Individual research under the supervision of a member of the staff. Research areas include organic, physical, inorganic, analytical, and biological chemistry.

CHEM C3443x-C3444y Organic Chemistry (Lecture) 3.5 pts. Prerequisites: CHEM C1404 or W1404 or C1604, and W1500. The principles of organic chemistry. The structure and reactivity of organic molecules are examined from the standpoint of modern theories of chemistry. Topics include stereochemistry, reactions of organic molecules, mechanisms of organic reactions, syntheses and degradations of organic molecules, and spectroscopic techniques of structure determination. Recitation Section Required.

CHEM W3443x-W3444y Organic Chemistry (Lecture) 3.5 pts. Prerequisites: CHEM C1404 or W1404 or C1604, and W1500. The principles of organic chemistry. The structure and reactivity of organic molecules are examined from the standpoint of modern theories of chemistry. Topics include stereochemistry, reactions of organic molecules, mechanisms of organic reactions, syntheses and degradations of organic molecules, and spectroscopic techniques of structure determination. Recitation Section Required.

BIOC C3501x Biochemistry, I: Structure and Metabolism 4 pts. Prerequisites: ENVB W2001 or BIOL C2005 and one year of organic chemistry. Lecture and recitation. Students wishing to cover the full range of modern biochemistry should take both BIOC C3501 and C3512. Protein structure, protein folding, enzyme kinetics, allostery, membrane transport, biological membranes, and protein targeting. Chemistry and metabolism of amino acids, carbohydrates, lipids, purines, and pyrimidines. Recitation Section Required.

BIOC C3512y Molecular Biology 3 pts. Prerequisites: One year of biology and one year of organic chemistry. Recommended but not required: BIOC C3501. Nucleic acid structure and enzymology. DNA replication, DNA repair, and transcription. RNA processing and translation. Biochemical approach to the study of gene expression and regulation with emphasis on the diseases caused when the basic processes are altered. Students may take BCHM G4026 in place of this course. Recitation Section Required.

CHEM W3543x or y Organic Chemistry Laboratory 3 pts. Prerequisites: CHEM W1500 Corequisites: CHEM C3443 or W3443. Laboratory Fee: $125. Students planning to take a full year of laboratory should enroll in CHEM W3543 and W3546. Techniques of experimental organic chemistry, with emphasis on understanding fundamental principles underlying the experiments in methodology of solving laboratory problems involving organic molecules.

CHEM W3545x Intensive Organic Chemistry Laboratory 3 pts. Prerequisites: CHEM C3045 and C3046 and W2507. Laboratory Fee: $125. The course covers the same material as CHEM W3543, but is intended for those students who have taken Intensive Organic Chemistry for First-Year Students, CHEM C3045-C3046 and for students who are intending to major in Chemistry, Biochemistry, Chemical Physics or Environmental Chemistry.

CHEM W3546y Advanced Organic Chemistry Laboratory 3 pts. Prerequisites: CHEM W3543 or W3545. Corequisites: CHEM C3444 or W3444. Laboratory Fee: $125. A project laboratory with emphasis on complex synthesis and advanced techniques including qualitative organic analysis and instrumentation.

CHEM C3920x Senior Seminar in Chemical Research 2 pts. Open to senior chemistry, biochemistry, environmental chemistry, and chemical physics majors, senior chemistry concentrators, and students who have taken or are currently enrolled in CHEM C3098. Pass/Fail credit only. Senior seminar provides direct access to modern chemical research through selected studies by the students from active fields of chemical research. Topics to be presented and discussed draw from the current scientific literature and/or C3098 research.

This course does not count toward a concentration in chemistry.

BIOC G4026y Biochemistry of Nucleic Acids and Protein Synthesis 4.5 pts.Not offered in 2013-2014. Prerequisites: BCHM G4021, or the equivalent, BIOC C3501. Structure and organization of chromatin, nucleic acid hybridization and sequence complexity of DNA, DNA and RNA sequencing methods, current views of replication and repair, transcription and translation, regulation of nucleic acid and protein synthesis, recombinant DNA techniqes, gene transfer and gene duplication. Discussion of original papers and evaluation of experimental procedures and conclusions.

CHEM G4071x Inorganic Chemistry 4.5 pts. Prerequisites: C3443-C3444 or C3045-C3046 Corequisites: N/A Principles governing the structure and reactivity of inorganic compounds surveyed from experimental and theoretical viewpoints. Topics include inorganic solids, aqueous and nonaqueous solutions, the chemistry of selected main group elements, transition metal chemistry, metal clusters, metal carbonyls, and organometallic chemistry.

CHEM G4103y Organometallic Chemistry 4.5 pts. Prerequisites: Elementary organic chemistry. (Some background in inorganic and physical chemistry is helpful but not required.) Main group and transition metal organometallic chemistry: bonding, structure, reactions, kinetics, and mechanisms.

CHEM G4137y Photonics & Spectroscopy 4.5 pts.Not offered in 2013-2014. Prerequisites: N/A Corequisites: N/A Powerful photonics and spectroscopy tools are changing the way many physical and biological problems are addressed by revealing direct and precious energetic and dynamic information of molecular species inside live cells or novel materials. This full semester graduate course will not only provide fundamental knowledge of optics, laser, photonics, linear and nonlinear molecular spectroscopy, but also introduce physical principles of various emerging optical techniques including femotosecond spectroscopy, single-molecule spectroscopy, multi-photon nonlinear microscopy, label-free chemical imaging, super-resolution imaging, optical coherence tomography. Discussion Section Required.

CHEM G4145y NMR Spectroscopy 1 pt. Prerequisites: Elementary organic chemistry. Introduction to theory and practice of NMR spectroscopy. Instrumental aspects, basic NMR theory, NOE, and a survey of 2D methods are covered.

CHEM G4147x Advanced Organic Chemistry 4.5 pts. Prerequisites: Elementary organic and physical chemistry. The mechanisms of organic reactions, structure of organic molecules, and theories of reactivity. How reactive intermediates are recognized and mechanisms are deduced using kinetics, stereochemistry, isotopes, and physical measurements.

CHEM G4148x Synthetic Methods in Organic Chemistry I 4.5 pts. Construction, analysis and strategies for the synthesis of complex natutal products.

CHEM G4168x Materials Chemistry I 4.5 pts. Prerequisites: Sophomore Organic and Inorganic Chemistry This course will have two main themes. One theme will explore the design, synthesis, and properties of materials made from molecules. Topics that will be covered in this section of the course include the chemistry of liquid crystals, self-assembled monolayers, organic electronics, carbon-based nanostructures, self-assembled materials, and bio-inspired materials. A second theme will explore inorganic materials. It will compare the chemistry of chemical vapor deposition and vapor phase epitaxy to make solid state materials. It will further study the transformation from chemical bonds to solid-state band structure in materials and quantum size effects.

BIOC G4170y Biophysical Chemistry 4.5 pts. Prerequisites: Elementary physical and organic chemistry. Recommended preparation: elementary biochemistry. Tactics and techniques for the study of large molecules of biological importance, analysis of the conformation of proteins and nucleic acids; hydrodynamic, scattering, and spectroscopic techniques for examining macromolecular structure.

CHEM G4172y Biorganic Topics 4.5 pts. Prerequisites: Elementary organic chemistry. Recommended preparation: advanced organic chemistry. Various topics in bioactive molecules in the field centered on natural-products chemistry, metabolic transformations, and enzyme mechanisms. Biosysnthesis of natural products and some other bioorganic topics.

CHEM G4210y Writing Workshop for Chemists 1 pt. Prerequisites: Recommended for undergraduate students to have taken at least one semester of independent research. This course offers undergraduate and graduate students an introduction to scientific writing and provides an opportunity for them to become more familiar with the skill and craft of communicating complex scientific research. This course will provide students with the basic grammatical, stylistic and practical skills required to write effective academic journal articles, theses, or research proposals. In addition, through an innovative partnership with Columbia University Libraries' Digital Science Center, students will learn how to apply these basic skills to their writing through the use of state-of-the-art software and online resources. Regular opportunities to write, peer edit and revise throughout the semester will allow students to put what they are learning into immediate practice. It is recommended that undergraduates have taken at least one semester of research for credit before taking this course. Undergraduates should plan to take this course after taking the required Core course University Writing.

CHEM G4221x Quantum Chemistry 4.5 pts. Prerequisites: Elementary physical chemistry. Basic quantum mechanics: the Schrodinger equation and its interpretation, exact solutions in simple cases, methods or approximation, angular Mementum and electronic spin, and an introduction to atomic and molecular structure.

CHEM G4230x Statistical Thermodynamics. 4.5 pts. Prerequisites: Elementary physical chemistry. Corequisites: CHEM G4221 Topics include the classical and quantum statistical mechanics of gases, liquids, and solids.

BIOC W4312x Chemical Biology 4 pts. Prerequisites: Elementary organic chemistry CHEM C3443, CHEM C3444. Recommended preparation elementary physical chemistry and biochemistry CHEM C3079 CHEM C3080. Development and application of chemical methods for understanding the molecular mechanisms of cellular processes. Review of the biosynthesis, chemical synthesis, and structure and function of proteins and nucleic acids. Application of chemical methods--including structural biology, enzymology, chemical genetics, and the synthesis of modified biological molecules--to the study of cellular processes--including transcription, translation, and signal transduction.

CHEM G6222y Quantum Chemistry II 2.5 pts. Prerequisites: Quantum Chemistry G4221 Atomic and molecular quantum mechanics: fundamentals of electronic structure, many-body wave functions and operators, Hartree-Fock and density functional theory, the Dirac equation.

CHEM G6241y Chemical Dynamics 2.5 pts.Not offered in 2013-2014. Prerequisites: Chemistry G4221 or the equivalent. Theory of the rates and temperature dependence of chemical reactions in gases and liquids.

CHEM G6242y Interfaces and Condensed Phases 2.5 pts.Not offered in 2013-2014. Prerequisites: Chemistry G4221 and G4230 or their equivalents. Elements of the physical chemistry and electronic structure of interfaces and solid materials with application to organic conductors and semiconductors.

CHEM G6251y Spectroscopy 2.5 pts. Prerequisites: Chemistry G4221 or the equivalent. Principles of the interaction of molecules with radiation. Applications of spectroscopy to elucidate molecular structure and bonding.

CHEM G8106y Kinetics 2.5 pts.Not offered in 2013-2014. Kinetics and mechanisms of inorganic reactions.

CHEM G8110x Applications of Transition-Metal Organometallics to Polymer Chemistry 2.5 pts.Not offered in 2013-2014. The use of transition-metal complexes as catalysts for olefin polymerization, and for atom transfer and chain transfer during free-radical polymerizations.

CHEM G8111y Applications of NMR Spectroscopy to Inorganic Chemistry 2.5 pts. The use of multinuclear NMR spectroscopy in the determination of the structures of inorganic molecules and the use of dynamic NMR spectroscopy (variable temperature NMR and magnetization transfer techniques) to provide information concerned with reaction mechanisms.

CHEM G8120y Polymers in Nanotechnology 2.5 pts. Prerequisites: N/A Corequisites: N/A Polymeric materials have long been ubiquitous items and played important roles in revolutionizing the way we live. Due to the advent of modern polymerization fabrication strategies, polymers are rapidly gaining interest for the development of next generation devices and medical treatment. This course will focus on the chemistry polymers and their use as nanostructured materials created by self-assembly and top-down fabrication techniques. Specifically, the class will be divided into two sections describing the uses of organic nanostructures on a) surfaces and b) as particles. Patterned surfaces will be described in terms of photo-, imprint-, and block copolymer lithography. The preparation of nanoparticles through polymer synthesis, dendrimers, and mechanical manipulation will be the second part.

CHEM G8130x The Chemistry of Nanocrystals 2.5 pts.Not offered in 2013-2014. This course will provide a discussion of the thermodynamics and kinetics of colloidal crystallization and stabilization, the physical properties of quantum confined semiconductor and metal nanocrystals, methods of nanocrystal characterization, and examples of nanocrystals in technological applications. Prospective students should be familiar with basic principles of quantum mechanics, thermodynamics of phase transitions, and inorganic chemistry - particularly molecular orbital theory. Undergraduate students interested in this course should obtain approval from the instructor prior to registering.

CHEM G8149y Synthetic Methods in Organic Chem. II 4.5 pts. Prerequisites: CHEM G8148. Construction, analysis, and strategies for the synthesis of complex natural products.

BIOC G8200x Optical Bio-imaging 2.5 pts.Not offered in 2013-2014. Powerful optical imaging tools are changing the way many biological problems are addressed by revealing direct and precious visualization information inside live cells, tissues and organisms. This interdisciplinary course will not only provide fundamental knowledge of optics, laser, microscopy, linear and nonlinear molecular spectroscopy, but also introduce physical principles of various emerging microscopy techniques including single-molecule biophysics, multi-photon microscopy, label-free chemical imaging, super-resolution imaging, novel molecular probes, optical coherence tomography and emerging technology. A few guest lectures from expert instructors across the campus are expected. Discussion Section Required.

CHEM G8232y Advanced Statistical Mechanics 2.5 pts. Prerequisites: Chemistry G4221 and G4230 or their equivalents. Stochastic processes; Brownian motion; Langevin equations and fluctuation-dissipation theorems; reaction rate theory; time correlation functions and linear response theory.

CHEM G8252y Special Topics in Physical Chemistry 2.5 pts.Not offered in 2013-2014. Prerequisites: Chemistry G4221 or the equivalent. Problems and methods in areas of current research interest.

CHEM G8300y Biophotonics 2.5 pts. Biophotonics tools are changing the way many biological problems are addressed by revealing direct and precious visualization information inside live cells, tissues and organisms. This interdisciplinary course will not only provide fundamental knowledge of optics, laser, microscopy, linear and nonlinear molecular spectroscopy, but also introduce physical principles of various emerging microscopy techniques including single-molecule biophysics, multi-photon microscopy, label-free chemical imaging, super-resolution imaging, novel molecular probes, optical coherence tomography and emerging technology. A few guest lectures from expert instructors across the campus are expected.

CHEM G8310y Transition Metals in Organic Synthesis 2.5 pts.Not offered in 2013-2014. Recent advances in the development of homogeneous catalysis for selective organic synthesis. Emphasis on both mechanistic and synthetic aspects.

CHEM G8313x Modern Molecular Photochemistry of Organic Compounds 2.5 pts.Not offered in 2013-2014. Review of principles of the mechanisms of organic photochemical reactions.

CHEM G8316y Supramolecular Chemistry 2.5 pts. Prerequisites: G4147 or permission from the instructor. Intermolecular interactions are at the structure-reactivity and structure-function relations of many issues in material sciences and biological chemistry. This course will describe the fundamental concepts and methodologies of the field and review its development over the past several decades. Emphasis will be placed on guest-host systems which can be developed based on the paradigm of the chemistry of enzymes.

CHEM G9303x-G9303y (Section 1) Investigation of Special Problems in Chemistry 1-12 pts. Points to be arranged.Not offered in 2013-2014. Individualized research projects.

CHEM G9307x-G9307y (Section 1) Research for the Doctorate 1-12 pts. Pass/Fail Department's permission.